Ten-year recurrence outcomes in early stage and early onset colon cancer and the expression profiles of microRNAs and cancer stem cell markers in these tumors

Objective: We hypothesized that microRNAs (miRNAs) might be involved in tumor development by critically regulating cancer stem cell (CSC) markers the early stages of colon (eCC). This study aimed to determine expression profiles miRNAs CSC-positive eCC patients and examine their associations with recurrence. Materials Methods: analyzed CD133, LGR5 SOX2 CSC status 30 specimens. Then, using results RT2 miRNA PCR custom arrays, we evaluated 38 patients. Results: Recurrence occurred 5 within ten years after surgery. determined down-regulation miR-125b up-regulation miR-135b were significant (p=0.021, p=0.001, respectively). found low was associated recurrence (p=0.0022). Conclusions: suggest prevented increasing eCC.